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Spatial transcriptomics combined with single-cell RNA sequencing identified high expression levels of ferroptosis-related genes, including TFRC, NCO4, and SLC3A2, in granulosa cells of patients with ovarian senescence, while GPX4 expression was notably low ( BNC1 mutations that lead to premature follicular activation and atresia (Zhang et al., 2018)

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Flavonoids have lower redox potentials hence are able to reduce highly oxidizing free radicals by forming less reactive flavonoid radicals

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