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Amino Acids, 2012, 2012, 1-26

The SelenoP family has recently evolved, and SelenoP homologues are found predominantly in vertebrates

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Animal models are inherently costly, and the underlying mechanisms do not always translate to human disease processes ( in vitro 2D and 3D models are vastly different from the in vivo environment, making it difficult to fully understand the various factors affecting the neurovascular unit and pathways and mechanisms contributing to neuroinflammation

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Another apparently general host response to bacterial pathogens is the activation of the transcription factor HIF-1 by stabilization of the HIF-1 subunit through hypoxic conditions caused by infections or pathogen-induced signaling (Rupp et al., 2007