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The specific process involves exchange of glutamate produced from glutamine for cystine (which is rapidly reduced to intracellular cysteine) via the SLC7A11 and SCL3A2), which in turn can synthesize glutathione with glutamate, cysteine, and glycine (Fig

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People with higher levels of oxidative stress or lower baseline glutathione may notice more dramatic benefits from supplementation compared to those with already-optimal levels