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It traces the transition from traditional oxygen-based detection (first generation) to mediator-based electron transfer (second generation) and finally to direct electron transfer between the enzyme and electrode (third generation)

Abstract Angiogenesis is crucial for normal development and homeostasis, but also plays a role in many diseases including cardiovascular diseases, autoimmune diseases, and cancer

However, this assessment is primarily clinician-driven, relatively subjective, and lacks objective data, which may lead to significant variability depending on the evaluator (Park et al., 2019

Regulation of exocytosis by protein kinase C

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