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The body produces limited creatine, but you boost creatine stores by consuming creatine-rich foods (e.g., red meat) or supplements

Erratum in: 2003, Gastroenterology124(1):275

Effect of GDH2 and GDH3 gene deletions on the metabolic state of C

Oxidative stress is implicated in the pathogenesis of IC/BPS as reactive oxygen species impair bladder function via their involvement in multiple molecular mechanisms

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whereas in the mitochondria, NAD + is reduced to NADH by MDH2 coupled with the oxidation of malate back to OAA in the TCA cycle (106)