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suggesting that, at high concentrations, IGF-1 has effects not simply mediated by suppressing the effect of GH on hepatic insulin sensitivity [129, 209]

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[6] Scientists working with test models also comment that IGF-1 may have a GH independent growth stimulating effect, which with respect to cartilage cells is possibly optimized by the synergistic action with GH

Exposure to excessive heat, moisture, or light can degrade the vitamin and lead to potential complications when administered

In this synthesis of existing observations, we approach this issue through the examination of reported biomarker responses, which are universally recognized as quantitative metrics of vitamin B-12 status (2935)