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6,7 How Sermorelin Supports Muscle Preservation in GLP-1 Users GLP-1 receptor agonists such as semaglutide can reduce muscle mass by lowering appetite, caloric intake, and indirectly decreasing anabolic signaling through the GHIGF-1 axis

To test this hypothesis, we investigated the subcellular localisation of proIGF-1s by cytosol, ER and nucleus isolations (Fig

P -values below 0.05 were considered significant and are indicated in the graphs