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Table 1 summarizes key studies that elucidate the involvement of mtDNA in mediating neuroinflammatory responses in PD

3.3 GDC-treated monolayers have a higher permeability to lactulose To evaluate whether decreased TEER values in GDC-treated monolayers corresponded to increased permeability, a lactulose permeability assay was performed on these monolayers (Figure 1C)

Studies have shown that tumor necrosis factor alpha-induced protein 8-like 1 (TNFAIP8L1/TIPE1) could regulate PINK1/Parkin-mediated mitochondrial autophagy to protect renal function in DKD

In addition, activated T cells express CD40L, which can activate the CD40 receptor expressed by B cells and by monocytes/macrophages

Somayajulu M, McCarthy S, Hung M, Sikorska M, Borowy-Borowski H, Pandey S (2005) Role of mitochondria in neuronal cell death induced by oxidative stress

Ethics declarations Ethical approval Human scalp tissue was obtained with approval from the Global Medical Research Center Institutional Review Board (IRB No