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Severe vitamin B12 deficiency affects about 3 percent of adults in developed countries, but a more marginal deficiency may impact 26 percent, with the highest rates among adults older than 60

Our bodies are constantly producing free radicals (uncharged, highly reactive molecules with unpaired electrons)

While in vitro equilibrations between redox couples such as roGFP2 and GSH/GSSG require minutes or even hours to reach a thermodynamic endpoint (G = 0), enzyme-catalyzed thiol-disulfide exchange reactions usually occur very rapidly and either maintain or reach a steady state (G 0) 7,31,32,60,63,67,78,79

[DOI] [PubMed] [Google Scholar] 133.van Gool J.D., Hirche H., Lax H., De Schaepdrijver L

Nat Genet 2002;32:261-6