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To determine whether reducing either or both sources of serine affects carboplatin efficacy in vivo, we injected NCI-H520 cells into the flanks of athymic, immunodeficient mice and fed them either complete amino acid-based diet (Ctrl diet), a high-serine diet (High S diet), a serine-deficient diet (-S diet) or a serine and glycine-deficient diet (-SG diet)

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