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Description

2021;7(12):eabe3588

Science of the Total Environment, 579 (1), 93106

88 Patients received NAC, 12002400 mg per day, or placebo for 12 weeks in this trial

Overexpression of lipid transport protein 2 leads to inhibition of ferroptosis, which ultimately increases the resistance to 5-fluorouracil

NRF2 promotes the synthesis of GSH from glutamate and the production of monounsaturated fatty acids catalyzed by SCD1both of which are critical mediators of ferroptosis resistance