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Miao, H., et al

bioRxiv2026 Jan 9

5-7

Comparative study of functional food regulations in Japan and globally

The IGF-IGFR-IGFBP axis The insulin-like growth factor (IGF) axis encompasses the growth factors IGF-1 and IGF-2, the type 1 and 2 IGF receptors (IGF1R and IGF2R), and a group of six binding proteins (IGFBP-1 to -6) with high affinity for IGF-1 and IGF-2

4 Symptoms include: 4 joint pain usually symmetrical on both sides of the body and often throbbing or aching which is worse in the morning or after being inactive such as sitting for a while joint stiffness often worse in the morning for more than 30 minutes or after inactivity swollen, hot, tender joints joint deformity (misshapenness) if joints are damaged more general symptoms such as fatigue, fever, sweating, loss of appetite and weight loss dry eyes or chest pain Symptoms are different for each person and some people experience periods when symptoms become worse called a flare or flare-up