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reported that higher melatonin metabolite concentrations (urinary 6-sulfatoxymelatonin: UME) are associated with significantly lower cognitive performance in the MMSE ( n = 935) and in the Geriatric Depression Scale ( n = 1,097) [259]

Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis

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et al.: Age-induced accumulation of methylmalonic acid promotes tumour progression (2020) Nature | DOI: 10.1038/s41586-020-2630-0