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10.1098/rstb.2000.0707 Philos

Surgical treatment for acute pancreatitis and pancreatic necrosis

These ROS oxidize PUFAs in cell membranes into lipid peroxides (PUFA-OOH), thereby destroying cell membrane structural stability, attacking cellular DNA and proteins, and causing ferroptosis

Furthermore, diverse adhesive domains/motifs, such as oligomerization domains, coiled coils, and -zippers, provide multiple intramolecular and intermolecular interactions (Fig