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The preferential engagement of mitochondrial and bioenergetic pathways in the PFC, relative to the NAc, points to region-specific vulnerability to early-life stress and stress-THC co-exposure, aligning with prior evidence that peripubertal stress more strongly recruits metabolic gene networks in the PFC than in striatal regions [66]

Mu-opioid and dopamine-D2 receptor expression in the nucleus accumbens of male Sprague-Dawley rats whose sucrose consumption, but not preference, decreases after nerve injury

It plays a vital role in detoxification, immune support, and neutralizing free radicals that cause oxidative stress

109 The Nrf2 coordinates the basal and stress-inducible activation of the glutamate-cysteine ligase complex 110 and regulates the transcription of glutathione peroxidase 2 and glutathione S-transferases

[78] formulated nanocomposite poloxamers (PLX)/ZnO incorporating CA extract (CAE) for treating diabetic wounds