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BPC-157 demonstrates exceptional safety in animal toxicology studies, with comprehensive evaluations in mice, rats, rabbits, and dogs failing to establish a lethal dose (LD) across wide dose ranges extending from standard research doses (6 g/kg) to levels exceeding 1000-fold higher concentrations (20 mg/kg), with no evidence of acute toxicity, organ-specific damage, or systemic adverse effects even following repeated high-dose administration

Consider treatment response and tolerability when selecting the maintenance dosage Cardiovascular risk reduction maintenance dose: Either 2.4 mg (recommended) or 1.7 mg once weekly, based on patient response and tolerance

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In the STEP 1 trial, once-weekly semaglutide 2.4 mg plus lifestyle intervention produced about 14.9% mean weight loss at 68 weeks, compared with about 2.4% with placebo