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In agreement with this, ENDO12 showed increased inhibitory activity in cell-based assays compared to ENDO3 (Fig

2008 Jun 1114

Under physiological conditions, ROS are generated in the heart mainly from the mitochondrial electron transport chain, nitric oxide synthases (NOS), NADPH oxidases (NOX), and xanthine oxidase (XO) in small quantities [7, 8]

It has been shown that GDNF administration by catheter increases dopaminergic neuronal resistance against 6-OHDA toxicity, but with preservation of motor functions in rat and rhesus monkey models [96]