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Overproduction of ROS is likely to be important in enhancing TMZ sensitivity ( Figure 5 ), sorafenib alters TMZ sensitivity via autophagy and the JAK2/STAT3-AIF axis, and this alteration can be reversed by ROS clearance (176)

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At high pH ( 5.0), the coordination interaction will be inhibited by hydroxyl groups, and only at high salt concentration can efficient adsorption be obtained [55]

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