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SERCA2b mutation accelerates the depletion of ER Ca 2+ , promotes ERS, and aggravates the stimulation of glutamate to HT22 cells excitotoxicity [114]

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Su H, Yuan P, Lei H, Zhang L, Deng D, Zhang L, et al

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J Pharmacol Exp Ther , 227: 749754, 1983

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However, the effect was diminished by Inhibitors of PI3k and Akt, indicating that PI3/Akt pathway is important for cell growth induced by IGF-1 [2]

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Summary and future directions Therapeutic resistance and suboptimal efficacy remain significant challenges in CD management

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