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doi: 10.1111/vop.12693

NAD+ plays crucial roles in maintaining genomic stability through its function as a substrate for poly(ADP-ribose) polymerases (PARPs), a family of enzymes that detect and respond to DNA damage by catalyzing the synthesis of poly(ADP-ribose) polymers from NAD+

To mitigate translational risk, phase 0 microdosing studies using 89 Zr-labeled nanoparticles are proposed to assess human biodistribution prior to efficacy trials [225]

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