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These mutations disrupt the normal oxidative decarboxylation of ICT to -KG, conferring a neomorphic catalytic activity that reduces -KG to D -2HG, consuming NADPH in the process ( Scheme 1 )

Srensen N, Murata K, Budtz-Jrgensen E, Weihe P, Grandjean P, Sorensen N et al (1999) Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Schrezenmeier E, Dorner T

Coveney S, McCabe JJ, Murphy S, Belton O, Gray C, Cassidy T, Kelly PJ (2021) Dose-dependent association of inflammatory cytokines with carotid atherosclerosis in transient ischaemic attack: implications for clinical trials

This enhances Ca 2+ influx, which subsequently activates ADP-ribosyltransferase (ARTD1/PARP1), leading to energy-consuming poly-ADP-ribosylation and caspase cleavage, not to induce apoptosis, but paradoxically to inhibit it

Proprietary alpha-amylase inhibitor formulation from white kidney bean ( Phaseolus vulgaris L.) promotes weight and fat loss: a 12-week, double-blind, placebo-controlled, randomized trial