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None of this is theoretical

It is produced from the precursor thyroglobulin (this is not the same as thyroxine-binding globulin [TBG]), which is cleaved by enzymes to produce active T 4

doi: 10.1016/j.tplants.2012.04.005 78 KepplerL

Brain 133, 713726

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Methods: We retrospectively analyzed a large national insurance registry (Optum) between 2015-2019, including adults with at least 180 days of enrollment