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Pharmacodynamics: The observed pharmacodynamic effects in animal models often outlast measurable systemic exposure, suggesting mechanisms that include local tissue modulation, induction of growthfactor expression, and initiation of reparative cascades rather than sustained receptor occupancy requiring prolonged systemic presence

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In the cases of enteritis or colitis, you may also see rapid weight loss

Tender points, by comparison, are associated with pain at the site of palpation only, are not associated with referred pain, and occur in the insertion zone of muscles, not in taut bands in the muscle belly