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The lack of success at Phase III was attributed to factors such as high baseline immunosuppressive therapy in patients and complex disease mechanisms in SLE, potentially limiting the application of Rituximab as a monotherapy in SLE (119)

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The expression of APX isoforms can be activated by specific factors such as pathogen attack, mechanical pressure, injury, ultraviolet (UVB) radiation, water deficiency, salt stress, low or high temperature, atmospheric pollution, and excess metal ions (reviewed in Shigeoka et al., 2002

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