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126 Mechanistically, most interactions involve modulation of hepatic enzymes and transporters, which can lead to subtherapeutic effects or heightened toxicity depending on whether the herb acts as an enzyme inducer or inhibitor

Plasmid and siRNA transfection The cells were transfected with plasmids or siRNA for STAT3 or GSTP1, respectively, with Lipofectamine 3000, as per the manufacturers instructions (Thermo Fisher Scientific, Waltham, USA)