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Therefore, we conclude that mitochondrial GSH depletion impairs the activity and stability of iron sulfur cluster containing proteins

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10.1007/s10517-021-05365-3 Summary Keywords osteoarthritis, ferroptosis, mitophagy, chaperone-mediated autophagy, reactive oxygen species, adenosine monophosphate (AMP)-activated protein kinase (AMPK), hypoxia-inducible factors Citation An F, Zhang J, Gao P, Xiao Z, Chang W, Song J, Wang Y, Ma H, Zhang R, Chen Z and Yan C (2023) New insight of the pathogenesis in osteoarthritis: the intricate interplay of ferroptosis and autophagy mediated by mitophagy/chaperone-mediated autophagy

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A common genetic variant in zinc transporter ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics

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Thus, autophagy produces a favorable/unfavorable outcome depending on the type of cell, the environment, and the period in which it occurs

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Metallomics 10 (2), 296308 (2018)

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