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However, metformin collapses the oxygen consumption rate (OCR) in our cell lines

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The C677T polymorphism (NCBI SNP cluster ID rs# 1801133) in MTHFR gene results in an alanine-to-valine (A222V) substitution which in turn causes a reduction in enzyme activity and subsequent elevation of plasma homocysteine [15, 16]

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Taken together, BSL helped to change the metabolism of BCAAs in the intestine, and might contribute to converting them to glutamine, but which bacteria had these functions deserved further study