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For example, neurons typically catabolize gamma-aminobutyric acid (GABA) to create NADH to support biosynthetic processes and breast tumor cells with a GABAergic phenotype have a strong growth advantage in the brain by converting GABA to succinate to boost the citric acid cycle (153)

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Constipated patients with comorbid depression exhibit more severe bloating, abdominal pain, and sense of incomplete evacuation, with lower defecation frequency and harder stool consistency (Koloski et al., 2002)