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Beyond mental health, higher glutathione levels have been linked to better visuospatial memory, and brain regions with higher concentrations appear more resilient to the effects of aging

Moreover, as mitochondria play a central strategic role in the activation and mode of cell death, mitochondrial GSH has been shown to critically regulate the level of sensitization to secondary hits that induce mitochondrial membrane permeabilization and release of proteins confined in the intermembrane space that once in the cytosol engage the molecular machinery of cell death

Antioxidant activity and nutritional status in anorexia nervosa: effects of weight recovery

Further, this activity is confined to CHAC1, as its homolog CHAC2 is absent from the mitochondria