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Many natural bioactive compounds (e.g., plant extracts and microbial metabolites) exhibit copper-binding properties and can modulate copper metabolism or induce cuproptosis

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Biochim Biophys Acta 1241:139176 Ziemiska E, Doliska M, Lazarewicz JW, Albrecht J (2000) Induction of permeability transition and swelling of rat brain mitochondria by glutamine

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Liver necrosis, jaundice, hepatorenal syndrome

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Perspective: targeting the JAK/STAT pathway to fight age-related dysfunction

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