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Autophagic degradation of ferritin in cytoplasm or lysosome, known as ferritinophagy, could lead to elevated intracellular iron levels, thereby accumulating ROS and eventually triggering ferroptotic cell death (Hou et al., 2016)

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Some patients benefit from one or the other depending on their lab results and symptoms

Cell Metab 15(6):827837 (Erratum in: 16(5):686) Mrquez J, Alonso FJ, Mats JM, Segura JA, Martn-Rufin M, Campos-Sandoval JA (2017) Glutamine addiction in gliomas