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[7] Yamamoto et al researched the frequency of occurrence as related to the treatment timeline, finding that the reaction will most commonly occur during the initial loading dose (61%), that a smaller fraction will occur over the next four hours (37%), and that the least frequent fraction occurs during the terminal taper (2%)

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Its individual, tho

[DOI] [PubMed] [Google Scholar] 112.Duerson K., Woltjer R.L., Mookherjee P., Leverenz J.B., Montine T.J., Bird T.D., Pow D.V., Rauen T., Cook D.G

I have suffered with this gradually since my early teens