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This suggests that AQP4 could be involved in the progression of both cytotoxic and vasogenic edema, where its acute increase aids the progression of cytogenic edema, and its sub-acute increase may resolve the vasogenic edema

Acknowledgements The authors thank members of their lab for support and reading of various sections of this Review, and their funders the Wellcome Trust, the Medical Research Council and The Scar Free Foundation

In contrast, deregulated regulatory networks would give rise to iron-dependent disorders including ferroptosis and closely implicated diseases, such as cancers, diabetes, and neurodegenerative diseases