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Crocin also demonstrated low CYP inhibitory promiscuity and was predicted as a non-AMES toxic, non-carcinogenic, and non-inhibitor of the hERG gene, with an acute oral toxicity class III, indicating relatively safe toxicity parameters

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Tumour Biol (2012) 33(5):126574

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PMID 15051884

The signs + and indicate the level of GT expression in tumor tissues measured by immunohistochemistry