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For a typical 4-week vial with weekly injections, four brief exposures totaling about 40 to 60 minutes is completely normal and has minimal impact on potency

It reduces shelf life from 28 days to under 72 hours and increases contamination risk with repeated needle entry

The 0.9% balances efficacy and safety

[11] Sarah Morton et al., Patellar Tendinopathy and Potential Risk Factors: An International Database of Cases and Controls, Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine ( 2017)

They are naturally occurring, biologically active, coenzyme forms of vitamin B12, the forms the body needs for cellular utilization