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10.1152/japplphysiol.00629.2013 93

In branched amino acid catabolism, the branched-chain -ketoacid dehydrogenase complex requires TPP to convert branched-chain -ketoacids into branched-chain acyl-CoA, which is then converted into acetyl-CoA and enters the citric acid cycle

29/01/2022 Source Abstract Background Valproic acid (VPA) poisoning is responsible for life-threatening neurological and metabolic impairments

Regular testing helps identify deficiencies early, preventing severe neurological problems

doi:10.1056/NEJMoa1915922 Cutlip D, Levin T

For instance, large amino acid-mimicking glutathione-CQDs exhibit high physiological stability, reduced protein corona formation due to steric amino acid shielding, and excellent water solubility, enhancing their suitability for intravenous administration while mitigating unintended biological interactions [188]