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Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

This observation is not surprising as the cereblon ligands are very similar to thalidomide, both containing multiple lactam moieties, and the non-enzymatic hydrolysis of thalidomide has been long understood (Schumacher et al

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The mean and median durations of partial response were 810 and 430 days, respectively

Well, these are just some of the conditions liked to a faulty enzyme called MTHFR

10.1038/sj.cdd.4401320 136 MannG