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Less severe but still problematic gastrointestinal reactions warrant dose holds and systematic side effect management

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This multi-level regulation keeps glutamate within its tight physiologic range. Excess causes excitotoxic neuronal death (as in stroke), while deficiency impairs learning and memory

Schneider et al., 2012)

Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin

Further adaptation of an aTF system as a CFE biosensor often involves promoter optimization