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Here are some of the ways in which glutathione can influence our ability to achieve restful sleep: Oxidative Stress and Sleep Disorders : Sleep deprivation can lead to increased oxidative stress, which may deplete glutathione levels in the body

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The hTDP-43-NLS transgene being overexpressed was a mutated TDP-43 that contained a defective nuclear localization signal (NLS), so TDP-43 could not translocate back into the nucleus and was retained and accumulated in the cytoplasm of cells