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However, roscovitine can also inhibit Cdk1, Cdk2, Cdk7, and Cdk9, the low selectivity for Cdk5 reduces its potential as a drug candidate targeting neurological disorders

Clinically common, non-oncology drugs may be one of the directions that can be tapped (33, 151)

It helps maintain a healthy scalp and may slow premature graying

In KCs, SIRT1 deacetylates the NF-B p65 subunit, inhibiting its transcriptional activity and reducing the expression of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6

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doi: 10.1038/s41584-024-01158-w 287 JiangXStockwellBRConradM