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The same group evaluated the efficacy of a mixture of a hot water extract and a supercritical carbon dioxide extract of CL (CLE) in a randomized, double-blind, placebo-controlled study ( n = 45/group) in overweight but healthy individuals aged 50 to 69 years

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However, these effects were partially reversed when cells were treated with EVs derived from VDAC1-knockdown AGSR cells ( Figure 5F )