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Clinical translation requires addressing challenges including cell-type specificity, development of disease-specific ferroptosis biomarkers, optimization of combination regimens, and careful safety assessment to avoid unintended effects such as myelosuppression or hepatorenal toxicity

Activated glial cells serve a crucial role in neuroinflammation and release soluble signaling molecules, including chemokines, pro-inflammatory cytokines, glutamate, prostaglandins, ROS, RNS and damaged mitochondria (62-64)

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doi: 10.3389/fcimb.2021.739707 156 KellyJRBorreYO' BrienCPattersonEEl AidySDeaneJet al

Methionine supply alters mammary gland antioxidant gene networks via phosphorylation of nuclear factor erythroid 2-like 2 (NFE2L2) protein in dairy cows during the periparturient period