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Telomerase deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation

Systematic evaluation of their dose-dependent pro-oxidant effects and potential hepatorenal toxicity is necessary to determine the safety window and provide a scientific basis for clinical dosing

The copper peptide activates specific genes that control collagen and elastin production

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These findings are also interesting from an IGF-1R targeting point of view because pharmacological modulations leading to an excess of MDM2 could be a manner to cause a selective IGF-1 inhibition and apoptosis in cancer cells

The redox behavior of the NAD + /NADH system is therefore influenced by 1) the pH of the solution, since hydrogen ions participate in the redox half-reaction, 2) the 8 protonation states of NAD + , due to its three basic moieties, 3) the 16 protonation states of NADH, due to its four basic moieties (two pyrophosphate moieties, an adenine ring, and an added dihydropyridine ring)