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Hickey, A

The main contribution of this paper was that they highlight the metabolic effects of partial mTOR pathway inhibition by rapamycin and rapalogs to economize resources when cells are exposed to nutrient deficiency and hypoxic conditions, which could promote survival of tumor cells hence, highlighting the use of dual mTORC1/mTORC2 inhibition because such inhibitors are able to target dividing cells more efficiently (220)

These studies emphasize the ability of these compounds to address various aspects of AD pathology

This reversible regulation is not just a protective measure

2.15 Flow cytometer analysis of macrophage polarization After treatments with different interventions, macrophages (RAW 264.7 or THP-1) were harvested and resuspended with PBS, followed by blocked using Fc Receptor Blocking Solution (Biolegend)

In models of Alzheimer's disease (AD), CR offers multiple benefits: it increases the production of antioxidants and anti-apoptotic proteins, boosts histone deacetylase activity, and elevates levels of brain-derived neurotrophic factor (BDNF)