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Tumor-associated macrophages (TAMs), important immunosuppressive cells in the microenvironment, are able to activate the Gli2/IGF-2/ERK1/2 signaling axis to promote TGF- secretion and thus mediate the migration, invasion and EMT of hepatocellular carcinoma cells (Huh-7 cells) (73)

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During 2-acetylaminofluorene-induced hepatocarcinogenesis in rats, MTHFR expression is downregulated early

After washing three times with PBS buffer, tissue sections were re-stained with hematoxylin for 5 min and immersed in 1% hydrochloric acid alcohol for seconds

J Biol Chem 291: 1319413205 Carey BW, Finley LW, Cross JR, Allis CD, Thompson CB (2015) Intracellular alphaketoglutarate maintains the pluripotency of embryonic stem cells

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