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They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins

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known as slow wave sleep) showed no significant changes (F (8,109.970) = 1.342, p = 0.230)

3B, C), whereas SCC13 cells showed a delayed response, with significant effects observed only after 72 h of exposure (Fig