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Two collagen types dominate: Type I collagen (mature tendon structure) Type III collagen (early repair phase) In rodent studies, BPC-157-treated tendons showed: Increased type I collagen deposition Improved fiber parallel alignment Better biomechanical strength This suggests influence over: TGF- signalling Matrix metalloproteinases (MMPs) Extracellular matrix remodelling enzymes Balanced ECM remodelling prevents disorganized scar tissue

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As it stands, Epitalons pharmacological profile is promising but incomplete, raising key questions about long-term safety, optimal dosing, and how to harness its effects in a reliable, standardized way

In those studies, we investigated the cardiac effects of PPAR activation (11, 13, 42) and showed that cardiomyocyte-specific overexpression of PPAR causes intramyocardial lipid accumulation and cardiac dysfunction (42)