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Although functional data supporting a trans- inhibition model were obtained when constitutive activation of JAK2 was shown with a JAK2 construct where the pseudokinase and KDs were swapped and this construct showed significant cytokine-independent activation only in the presence of wild-type JAK2 ( As the GHR ICD is intrinsically disordered with a number of transient secondary structures (94), the C-termini are likely a long distance apart in the inactivated receptor homodimer in a similar manner as illustrated in a recent full structural model of the PRLR (95)

Brockington, A

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Concentrations of D2HG and L2HG were normalized to cell numbers

doi: 10.1111/j.1364-3703.2006.00354.x

Water-soluble organophosphorus pesticides are likely to increase the risk of PD