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Our results indicate that monitoring the spatial distribution of [1- 13 C]6PG production from hyperpolarized -[1- 13 C]gluconolactone serves to demarcate tumor from surrounding normal-appearing contralateral brain, thereby highlighting the ability of hyperpolarized -[1- 13 C]gluconolactone to provide a readout of tumor burden in vivo

The existence of overlapping signaling pathways suggests that possible therapeutic interventions might be explored with the aim to favor one RCD over the other, since inhibition of one RCD may lead to activation of the other one

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The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

Zhao, Y., Long, M