is selenium is part of the glutathione peroxidase enzyme system and Selenoproteins: Mechanisms, Health Functions, and Emerging Applications Redox Enzymes - Creative Diagnostics

We use this wide cis window because the J:DO have greater linkage disequilibrium than natural populations

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Physiological and pathological ageing of astrocytes in the human brain

There are numerous point mutations and rearrangements that have been associated with an array of human diseases including Parkinsons disease, Alzheimers disease, diabetes, tumors (Wallace et al., 1999

Interestingly, SESTRINs were originally discovered as stress response proteins (Budanov et al., 2002) and were also identified to negatively regulate mTORC1 via the AMPK-TSC2 axis (Budanov and Karin, 2008), suggesting that they are part of a broader cellular response to suboptimal growth conditions (Lee et al., 2016)

Zhang et al., 2018